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MOZ-IN-3

Product Name
MOZ-IN-3
CAS No.
2055397-18-5
Chemical Name
MOZ-IN-3
Synonyms
MOZ-IN-3;KAT6B inhibitor;KAT6A inhibitor;MOZ-IN-3/WM-8014;WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR;N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide;N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide;WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014;1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide;[1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
CBNumber
CB03376843
Molecular Formula
C20H17FN2O3S
Formula Weight
384.42
MOL File
2055397-18-5.mol
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MOZ-IN-3 Property

Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml
form 
A crystalline solid
pka
7.15±0.25(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27402
Product name
MOZ-IN-3
Packaging
1mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
27402
Product name
MOZ-IN-3
Packaging
5mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
27402
Product name
MOZ-IN-3
Packaging
500μg
Price
$37
Updated
2024/03/01
TRC
Product number
M732725
Product name
MOZ-IN-3
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0022886
Product name
WM-8014
Purity
99.64%
Packaging
25mg
Price
$1100
Updated
2021/12/16
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MOZ-IN-3 Chemical Properties,Usage,Production

Description

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.

Uses

MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

storage

Store at -20°C

MOZ-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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MOZ-IN-3 Suppliers

China 48 United States 4 Global 52
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

2055397-18-5, MOZ-IN-3Related Search:

WM-2474 WM-3835 D18 2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine

  • MOZ-IN-3
  • KAT6A inhibitor
  • KAT6B inhibitor
  • WM-8014;WM 8014;WM8014;KAT6A INHIBITOR; KAT6B INHIBITOR
  • MOZ-IN-3/WM-8014
  • [1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide
  • 1,1'-Biphenyl]-3-carboxylic acid, 4-fluoro-5-methyl-, 3-(phenylsulfonyl)hydrazide
  • WM-8014,HAT,inhibit,Inhibitor,HATs,WM 8014,Histone Acetyltransferase,WM8014
  • N’-(4-Fluoro-5-methylbiphenyl-3-carbonyl)benzenesulfonohydrazide
  • N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
  • 2055397-18-5